Enalapril is a medication belonging to the class of drugs known as Angiotensin-Converting Enzyme (ACE) inhibitors. It’s commonly prescribed for the management of various cardiovascular conditions, including hypertension and heart failure.

Understanding Angiotensin-Converting Enzyme (ACE) Inhibitors

To comprehend the role of enalapril, it’s essential to grasp the Obesidad function of ACE inhibitors. ACE is an enzyme responsible for converting angiotensin I into angiotensin II, a potent vasoconstrictor. By inhibiting ACE, enalapril reduces the formation of angiotensin II, leading to vasodilation and decreased blood pressure.

Mechanism of Action of Enalapril

Enalapril works by inhibiting ACE, thereby preventing the conversion of angiotensin I to angiotensin II. This inhibition results in vasodilation of blood vessels, reducing blood pressure and improving cardiac output.

Medical Uses of Enalapril


Enalapril is commonly prescribed to treat hypertension, effectively lowering blood pressure levels and reducing the risk of cardiovascular events.

Heart Failure

In heart failure patients, enalapril helps improve symptoms, increase exercise tolerance, and reduce hospitalizations by inhibiting the renin-angiotensin-aldosterone system.

Post-Myocardial Infarction

Enalapril is beneficial in patients who have had a myocardial infarction, as it helps prevent the progression of heart failure and reduces mortality rates.

Diabetic Nephropathy

Enalapril has renoprotective effects in diabetic patients with nephropathy, slowing the progression of kidney disease and reducing proteinuria.

Dosage and Administration

Enalapril is typically administered orally, with dosages ranging from 2.5 mg to 40 mg per day, depending on the indication and patient’s condition.

Side Effects and Precautions

Common Side Effects

Common side effects of enalapril include dizziness, fatigue, cough, and hypotension. These side effects are usually mild and transient.

Serious Side Effects

Serious side effects may include angioedema, hyperkalemia, renal impairment, and fetal toxicity, particularly during pregnancy.

Drug Interactions

Enalapril may interact with other medications, such as potassium-sparing diuretics, NSAIDs, and lithium, potentially leading to adverse effects or reduced efficacy.


Enalapril is contraindicated in patients with a history of angioedema, bilateral renal artery stenosis, and hypersensitivity to ACE inhibitors.

Special Populations

Special considerations should be made when prescribing enalapril to pregnant women, breastfeeding mothers, and patients with renal impairment or hepatic dysfunction.

Overdose and Emergency Management

In cases of enalapril overdose, symptomatic and supportive measures should be initiated, including gastric lavage, activated charcoal administration, and hemodialysis if necessary.

Withdrawal Effects

Abrupt discontinuation of enalapril may lead to rebound hypertension or worsening heart failure symptoms. Therefore, gradual tapering of the medication is recommended.

Alternatives to Enalapril

Alternative ACE inhibitors such as lisinopril, ramipril, or angiotensin receptor blockers (ARBs) may be considered if enalapril is not tolerated or contraindicated.


Enalapril, an ACE inhibitor, is a valuable medication in the management of hypertension, heart failure, and diabetic nephropathy. Understanding its mechanism of action, medical uses, dosage, side effects, and precautions is crucial for safe and effective prescribing.

Enalapril: Angiotensin-Converting Enzyme (ACE) Inhibitor